Fat stores are regulated over
long periods of time by complex systems that involve input and feedback from
fatty tissues, the brain and endocrine glands like the pancreas and the
thyroid.� Overweight and obesity can result from only a very small positive
energy input imbalance over a long period of time. |
What elements of energy
regulation feedback systems are different in individuals?� How do these
differences affect energy metabolism and regulation? |
Rarely, people have mutations
in single genes that result in severe obesity that starts in infancy.� Studying
these individuals is providing insight into the complex biological pathways that
regulate the balance between energy input and energy expenditure. |
Do additional obesity
syndromes exist that are caused by mutations in single genes?� If so, what are
they?� What are the natural history, management strategy and outcome for
affected individuals? |
Obese individuals have
genetic similarities that may shed light on the biological differences that
predispose to gain weight.� This knowledge may be useful in preventing or
treating obesity in predisposed people. |
How do genetic variations
that are shared by obese people affect gene expression and function?� How do
genetic variation and environmental factors interact to produce obesity?� What
are the biological features associated with the tendency to gain weight?� What
environmental factors are helpful in countering these tendencies?�
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